I love to be bold when it comes to artwork. Nothing screams “look at me!” more than a piece that is over-sized and occupies a small space in such a way that it grasps your unflinching interest and never lets go.
Take this painting as an example - it’s unusually large size immediately draws your attention to it from anywhere in the room. It creates vertical movement, by forcing your eyes to look it up and down. From this particular view, the leather chairs and table below give the picture some grounding, while adding balance and symmetry.
The important thing to remember here is that one should never underestimate the power and impact of scale. If you can find a way to combine it with the rest of the room in such a way that it adds a touch of style and elegance, then the question of using it changes from a “why?” to a “where??”